If Ponce DeLeon had found the “Fountain of Youth”, what beneficial components might the water have contained?

It would have included all natural marine species such as:

Holothuria cinerascens (ashy sea cucumber), Spirulina pacifica (Hawaiian spirulina), Chalmys rubida (Pacific pink scallop), Strongylocentrotus franciscanus (giant red urchin), Holothuria mexicana (donkey dung sea cucumber), Haliotis fulgens (green abalone), Arthrospira platensis (spirulina), Stichopus chloronotus (greenfish sea cucumber), Stronylocentrotus purpuratus (purple urchin), Haliotus rufescens (red abalone), Holothuria scabra (sandfish, a sea cucumber), Ascophyllium nodosum (knotted wrack kelp), Macrocystis integrifolia (giant kelp), Microcystis aeruginosa (blue green algae)

Rejuvenation

The ingredients found in MBET Natural Marine Extract™ helps skin cells produce the components needed to rejuvenate the skin.

Thaweekitphathanaphakdee S, Chanvorachote P, Prateepchinda S, Khongkow M, Sucontphunt A. Abalone Collagen Extracts Potentiate Stem Cell Properties of Human Epidermal Keratinocytes. Mar Drugs. 2019 Jul 20;17(7):424. doi: 10.3390/md17070424. PMID: 31330853; PMCID: PMC6669461.

Resolving Wounds

The ingredients found in MBET’s patented Natural Marine Extract have been found to aid in resolving wounds including supporting neovascularization, re-epithelialization and formation of granulation tissue.

Lalzawmliana, V., Mukherjee, P., Roy, S., Nandi, S.K. (2023). Current Marine-Derived Materials for Tissue Regeneration Applications. Maia, F.R.A., Oliveira, J.M., Reis, R.L. (eds) Handbook of the Extracellular Matrix. Springer, Cham. https://doi.org/10.1007/978-3-030-92090-6_52-1

Zhihong Zheng, Mengqi Li, Pengfei Jiang, Na Sun, Songyi Lin, Peptides derived from sea cucumber accelerate cells proliferation and migration for wound healing by promoting energy metabolism and upregulating the ERK/AKT pathway, European Journal of Pharmacology, Volume 921, 2022, 174885, ISSN 0014-2999, https://doi.org/10.1016/j.ejphar.2022.174885.

Sofrona E, Tziveleka LA, Harizani M, Koroli P, Sfiniadakis I, Roussis V, Rallis M, Ioannou E. In Vivo Evaluation of the Wound Healing Activity of Extracts and Bioactive Constituents of the Marine Isopod Ceratothoa oestroides. Mar Drugs. 2020 Apr 18;18(4):219. doi: 10.3390/md18040219. PMID: 32325719; PMCID: PMC7230750.

Anti-Inflammatory

Marine compounds, including polysaccharides and peptides, have wide-ranging anti-inflammatory properties.

Xu J, Yi M, Ding L, He S. A Review of Anti-Inflammatory Compounds from Marine Fungi, 2000-2018. Mar Drugs. 2019 Nov 9;17(11):636. doi: 10.3390/md17110636. PMID: 31717541; PMCID: PMC6891400.

Elbandy M. Anti-Inflammatory Effects of Marine Bioactive Compounds and Their Potential as Functional Food Ingredients in the Prevention and Treatment of Neuroinflammatory Disorders. Molecules. 2022 Dec 20;28(1):2. doi: 10.3390/molecules28010002. PMID: 36615197; PMCID: PMC9822486.

Subramanya SB, Chandran S, Almarzooqi S, Raj V, Al Zahmi AS, Al Katheeri RA, Al Zadjali SA, Collin PD, Adrian TE. Frondanol, a Nutraceutical Extract from Cucumaria frondosa, Attenuates Colonic Inflammation in a DSS-Induced Colitis Model in Mice. Marine Drugs. 2018; 16(5):148. https://doi.org/10.3390/md16050148

Anti-Microbial

Studies of the marine species used in Natural Marine Extract have shown that they develop unique compounds to defend against infection from microbes found in their environment. White papers have shown that these antimicrobial properties are beneficial to human health.

Hughes CC, Fenical W. Antibacterials from the sea. Chemistry. 2010 Nov 8;16(42):12512-25. doi: 10.1002/chem.201001279. PMID: 20845412; PMCID: PMC3071975.

Kurhekar JV. Antimicrobial lead compounds from marine plants. Phytochemicals as Lead Compounds for New Drug Discovery. 2020:257–74. doi: 10.1016/B978-0-12-817890-4.00017-2. Epub 2020 Jan 24. PMCID: PMC7153345.

Karthikeyan A, Joseph A, Nair BG. Promising bioactive compounds from the marine environment and their potential effects on various diseases. J Genet Eng Biotechnol. 2022 Jan 26;20(1):14. doi: 10.1186/s43141-021-00290-4. PMID: 35080679; PMCID: PMC8790952.

Anti-Cancer

Studies have shown that marine extracts including marine triterpenoids found in Natural Marine Extract show anti-cancer properties.

Li Y-X, Himaya SWA, Kim S-K. Triterpenoids of Marine Origin as Anti-Cancer Agents. Molecules. 2013; 18(7):7886-7909. https://doi.org/10.3390/molecules18077886

Ru R, Chen G, Liang X, Cao X, Yuan L, Meng M. Sea Cucumber Derived Triterpenoid Glycoside Frondoside A: A Potential Anti-Bladder Cancer Drug. Nutrients. 2023 Jan 11;15(2):378. doi: 10.3390/nu15020378. PMID: 36678249; PMCID: PMC9861588.

Lee CG, Kwon HK, Ryu JH, Kang SJ, Im CR, Ii Kim J, Im SH. Abalone visceral extracts inhibit tumor growth and metastasis by modulating Cox-2 levels and CD8+ T cell activity. BMC Complement Altern Med. 2010 Oct 20;10:60. doi: 10.1186/1472-6882-10-60. PMID: 20961430; PMCID: PMC2972231.

Chaudhry GE, Islamiah M, Zafar MN, Bakar K, Aziz N, Saidin J, Sung YY, Tengku Muhammad TS. Induction of Apoptosis by Acanthaster planci sp., and Diadema setosum sp., Fractions in Human Cervical Cancer Cell Line, HeLa. Asian Pac J Cancer Prev. 2021 May 1;22(5):1365-1373. doi: 10.31557/APJCP.2021.22.5.1365. PMID: 34048163; PMCID: PMC8408404.

The formulation of Miracle of the Sea Natural Marine Extract Dietary Supplement Capsules is based on this literature.

The marine extracts we use in our products have been documented in white papers based on peer-reviewed studies to have a wide range of benefits, such as helping rejuvenate skin, helping heal damaged skin and providing anti-inflammatory, anti-microbial and anti-cancer properties.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. The information provided herein is intended for your general knowledge only and is not intended to be, nor is it, medical advice or a substitute for medical advice. If you have or suspect you have, a specific medical condition or disease, please consult your healthcare provider.